Topical Application of a Live Multi-Strain Lactobacillus Probiotic Concentrate with and without Azelaic Acid Improves Acne Severity

Reina Ito, Supervisor: Magdalena Rosell, Co-supervisors: Johanna M Gillbro, PhD & Ulf Åkerström, VP & CIO Skinome Master's Programme in Nutrition Science, 15 hp, Karolinska Institutet.

Prospective study | Split-face | Karolinska Institute | Acne

A well-balanced skin microbiome is crucial for skin health. Topical probiotics can help with acne by inhibiting C. acnes and reducing inflammation. Azelaic acid is an effective treatment option for mild to moderate acne.

Investigating the effects of topical probiotics and combination therapy with azelaic acid in the treatment of acne.

Prospective 4-week split-face study with 31 volunteers with active acne. Biophysical parameters were measured with an Antera 3D camera. Acne severity was evaluated using CASS for each half of the face.

Significant reduction in facial redness. CASS score significantly improved on the combination side (probiotics + azelaic acid). Probiotics alone showed a non-significant trend. No serious side effects.

Topical probiotics with live Lactobacillus can soothe the skin and improve acne. The combination with azelaic acid enhances the treatment effect.